PRESENTATIONS

RSS BLOG FEEDS


Welcome to LILE Editions, Brussels and Dr. Lilia Lens-Pechakova



 

GENETIC ENGINEERING AND CLONING

 

 

 

IN GENETIC ENGINEERING THE MAIN TASK IS TO FIND AND CHANGE THE GENE, RESPONSIBLE FOR AGING VIA GENETIC MODIFICATIONS, SURGERY OR CLONING.
EXAMENING GROUPS OF CENTENARIANS SHOWED THE EXISTANCE OF THE SAME GENE IN THE GROUP, GENES CALLED LONGEVITY GENES (FOR EXAMPLE SIRTUINS).
THEY USUALLY CONTROL THE GROWTH PROCESS AND METABOLISM BY DEACTIVATING THE HORMONE IGF (INSULIN GROWTH FACTOR) . TO CHANGE THE RESPONSIBLE GENE IS THE TASK OF THE GENETIC MODIFICATIONS.

ELONGATION OF THE TELOMERES DURING EMBRYOGENESIS IN THERAPEUTIC OR REPRODUCTIVE CLONING REPRESENTS ALSO ANOTHER WAY OF AGE EXTENSION.



RECENT RESULTS ON GENETIC MANIPULATIONS

 

"MAINTAINING THE FUNCTION OF THE THYMUS BY DELETING AN ENZYME ‘PAPPA’, CONTROLLING THE HORMONE IGF:...THE MICE LIVED MORE THAN 30% LONGER"

ABBE DE VALLEJO ET AL., PROC.NAT.AC.SC., JULY 2009

"DRUG PROVOKED GENETIC MODIFICATION ON OLDER MICE, DEACTIVATING ‘IGF1’: THE MICE LIVED 10% LONGER" HOLZENBERG ET AL. NOVEMBER 2008

"GENETIC MANIPULATED NOT TO PRODUCE A PROTEIN S6K1 FEMALE MICE, MIMICKING THE EFFECTS OF STRICT DIET: THE MICE LIVED 19% LONGERWITHERS D. ET AL., SCIENCE, OCTOBER 2009

"GENETIC MODIFICATION OF THE GENE "KLOTHO" ASSOCIATED WITH REGULATION OF GROWTH PROCESS AND METABOLISME AS IGF, SIRT etc. IN MICE:   30% LONGER PUBERTY DURATION AS WELL AS AGE EXTENTION."NATURE, OCTOBER, 2009

" STUDIES ON CENTENARIANS: ALL CENTENARIANS OF THIS GROUP HAVE THE SAME FORM OF A GENE FOXO3A", NEBEL ET AL., FEBRUARY 2009; ".:.. ALL FROM THIS GROUP HAVE THE GENE MUTATION, MAKING THE RECEPTORS OF ‘IGF1’ LESS ACTIVE" SCIENCE ET VIE, 2009


The discovery of the protective role of telomerase and telomeres on the chromosomes brought the scientists Blackburn, Greider, Szostak the Nobel prize for medicine in 2009.

Telomeres are at the end of the chromosomes, protecting them from fusing and our lifespan is limited by their shortening with every cell division.

Telomeres consist of tandemly repeated dna sequence TTAGGG, Where T, A and G represent the deoxyribonucleosides Thymidine, Adenosine And Guanosine.

When I was a UNESCO fellow at the Tokyo Institute Of Technology, I worked on modified nucleosides- more precisely the Uridine derivative (cmam5um2), found in t-RNA. (J.Org.Chem. 52 ,5060, 1987, Sekine M., Peshakova L., Hata Tsujiaki).

Later in Bulgaria and Belgium I also worked on modified nucleosides

 

Read my BLOG for recent news on Genetics and Life Extension



CLONING

"EMBRYONIC CELL-CLONED CATTLE HAVE LONGER TELOMERES and THERE ARE DIFFERENCES IN TELOMERE LENGTHS AMONG CLONED CATTLE DERIVED FROM DIFFERENT CELL TYPES,Norikazu Miyashita, Kazuho Shiga, Miharu Yonai, BIOL.REPR. 2002

"DURING EMBRYOGENESIS TELOMERASE IS STRONGLY ACTIVATED AND TELOMERES ARE ELONGATED IN BOVINE AND MURINE EMBRYOS" SCHAETZLEIN ET AL., REPR.&FERTILITY DEVELOPMENT, 2005



 

Bicycle Race, Check the InternetBikes Nl shop



The article is copyright protected and based on parts of my lecture "Science and Science Fiction toward Life Extension" in the TokyoTech & UNESCO Symposium, 2009



Specially collected from me thorough information on the scientific ways to life extension, pls refer to me and my Japanese lecture, you can find here:


Calorie restriction Life extension drugs Genetic Engineering Cloning


Nanotechnology Robotics Social Life Sport


Nature magazine Science magazine Europe health

Author&Webmaster LENS-PECHAKOVA